Dr. Zager has acted as a consultant and member of the scientific advisory board and received a grant from Delcath Systems Inc., has acted as a consultant and member of the scientific advisory board for IGEA and Amgen, and has acted as a consultant and member of the advisory board and received a grant from LifeCell. Dr. Messina has acted as a consultant for GlaxoSmithKline. Dr. Glass has a paid leadership position in Aurora Diagnostics LLC. Dr. Sondak has acted as a consultant and member of the advisory board for Merck & Co., Inc., Navidea Biopharmaceuticals, and Provectus Pharmaceuticals, Inc., and as a consultant for GlaxoSmithKline and Bristol-Myers Squibb.
Kerrin M. Green, MA, Assistant Managing Editor, JNCCN—Journal of the National Comprehensive Cancer Network
Ms. Green has disclosed that she has no relevant financial relationships.
Deborah J. Moonan, RN, BSN, Director, Continuing Education & Grants
Ms. Moonan has disclosed that she has no relevant financial relationships.
Ann Gianola, MA, Manager, Continuing Education & Grants
Ms. Gianola has disclosed that she has no relevant financial relationships.
Kristina M. Gregory, RN, MSN, OCN, Vice President, Clinical Information Operations
Ms. Gregory has disclosed that she has no relevant financial relationships.
SondakVKZagerJSMessinaJL. Primary tumor thickness as a prognostic factor in Merkel cell carcinoma: the next big thing?Ann Surg Oncol2012;19:3307–3309.
BichakjianCKLoweLLaoCD. Merkel cell carcinoma: critical review with guidelines for multidisciplinary management. Cancer2007;110:1–12.
HeathMJaimesNLemosB. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Assoc Dermatol2008;58:375–381.
LienMHGlassLFFenskeNA. Clinical recognition and diagnosis of Merkel cell carcinoma. In: SondakVKMessinaJLZagerJSDecontiRD eds. Merkel Cell Carcinoma: A Multidisciplinary Approach. London, United Kingdom: Imperial College Press; 2011:119–129.
MessinaJL. Pathology of Merkel cell carcinoma. In: SondakVKMessinaJLZagerJSDecontiRD eds. Merkel Cell Carcinoma: A Multidisciplinary Approach. London, United Kingdom: Imperial College Press; 2011:95–118.
RaoPBalzerBLLemosBD. Protocol for the examination of specimens from patients with Merkel cell carcinoma of the skin. Arch Path Lab Med2010;134:341–344.
SarnaikAAZagerJSCoxLE. Routine omission of sentinel lymph node biopsy for Merkel cell carcinoma ≤1 cm is not justified. J Clin Oncol2010;28:e7.
SchwartzJLGriffithKALoweL. Features predicting sentinel lymph node positivity in Merkel cell carcinoma. J Clin Oncol2011;29:1036–1041.
LimCSWhalleyDHayduLE. Increasing tumor thickness is associated with recurrence and poorer survival in patients with Merkel cell carcinoma. Ann Surg Oncol2012;19:3325–3334.
BreslowA. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg1970;172:902–908.
FieldsRCBusamKJChouJF. Five hundred patients with Merkel cell carcinoma evaluated at a single institution. Ann Surg2011;254:465–473.
SihtoHKukkoHKoljonenV. Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma. Clin Cancer Res2011;17:4806–4813.
TouzéALe BidreELaudeH. High levels of antibodies against Merkel cell polyomavirus identify a subset of patients with Merkel cell carcinoma with better clinical outcome. J Clin Oncol2011;29:1612–1619.
PaulsonKGCarterJJJohnsonLG. Antibodies to Merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in Merkel cell carcinoma patients. Cancer Res2010;70:8388–8397.
FieldsRCBusamKJChouJF. Recurrence after complete resection and selective use of adjuvant therapy for stage I through III Merkel cell carcinoma. Cancer2012;118:3311–3320.
Santamaria-BarriaJABolandGMYeapBY. Merkel cell carcinoma: 30-year experience from a single institution. Ann Surg Oncol2013;20:1365–1373.
Medina-FrancoHUristMMFiveashJ. Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases. Ann Surg Oncol2001;8:204–208.
KimJAChoiAH. Effect of radiation therapy on survival in patients with resected Merkel cell carcinoma: a propensity score Surveillance, Epidemiology, and End Results database analysis. JAMA Dermatol2013;149:831–838.
MojicaPSmithDEllenhornJD. Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin. J Clin Oncol2007;25:1043–1047.
StromTCaudellJJHanD. Radiotherapy influences local control in desmoplastic melanoma [published online ahead of print October 18, 2013]. Cancerdoi: 10.1002/cncr.28412.
O’ConnorWJRoenigkRKBrodlandDG. Merkel cell carcinoma. Comparison of Mohs micrographic surgery and wide excision in eighty-six patients. Dermatol Surg1997;23:929–933.
BoyerJDZitelliJABrodlandDGD’AngeloG. Local control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation. J Am Acad Dermatol2002;47:885–892.
GonzalezRJPadhyaTACherpelisBS. The surgical management of primary and metastatic Merkel cell carcinoma. Curr Probl Cancer2010;34:77–96.
VenessMFooteMGebskiVPoulsenM. The role of radiotherapy alone in patients with Merkel cell carcinoma: reporting the Australian experience of 43 patients. Int J Radiat Oncol Biol Phys2010;78:703–709.
GuptaSGWangLCPenasPF. Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: the Dana-Farber experience and meta-analysis of the literature. Arch Dermatol2006;142:685–690.
FieldsRCBusamKJChouJF. Recurrence and survival in patients undergoing sentinel lymph node biopsy for Merkel cell carcinoma: analysis of 153 patients from a single institution. Ann Surg Oncol2011;18:2529–2537.
LemosBDStorerBEIyerJG. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol2010;63:751–761.
StokesJBGrawKSDengelLT. Patients with Merkel cell carcinoma tumors ≤1.0 cm in diameter are unlikely to harbor regional lymph node metastasis. J Clin Oncol2009;27:3772–3777.
StarrittECUrenRFScolyerRA. Ultrasound examination of sentinel nodes in the initial assessment of patients with primary cutaneous melanoma. Ann Surg Oncol2005;12:18–23.
TuragaKKChauAEatridesJM. Selective application of routine preoperative axillary ultrasonography reduces costs for invasive breast cancers. Oncologist2011;16:942–948.
ChaiCYZagerJSSzabunioMM. Preoperative ultrasound is not useful for identifying nodal metastasis in melanoma patients undergoing sentinel node biopsy: preoperative ultrasound in clinically node-negative melanoma. Ann Surg Oncol2012;19:1100–106.
HrubyGScolyerRAThompsonJF. The important role of radiation treatment in the management of Merkel cell carcinoma. Br J Dermatol2013;169:975–982.
PrinceMDCruseCWSondakVKZagerJS. Surgical management of primary and regional Merkel cell carcinoma. In: SondakVKMessinaJLZagerJSDecontiRD eds. Merkel Cell Carcinoma: A Multidisciplinary Approach. London, United Kingdom: Imperial College Press; 2011:181–200.