EGFR-Mutated Lung Cancer With T790M-Acquired Resistance in the Brain and Histologic Transformation in the Lung

Restricted access

This case report describes the rare occurrence of a T790M resistance mutation found in a central nervous system (CNS) parenchymal metastasis. A concomitant squamous histology transformation in a lung non-T790M-resistant metastasis is also described. The authors hypothesize that this CNS resistance and histology transformation may have resulted from intermittent use of erlotinib treatment. This case report emphasizes the complexities of using erlotinib in the induction setting.

Correspondence: Kevin S. Scher, MD, MBA, Cedars-Sinai Tower Hematology Oncology Medical Group, 9090 Wilshire Blvd #200, Beverly Hills, CA 90211. E-mail: Kevin.Scher@cshs.org

Supplementary Materials

    • Supplemental Material (PDF 191 KB)
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 62 62 23
PDF Downloads 11 11 2
EPUB Downloads 0 0 0