1 From Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UCSF Helen Diller Family Comprehensive Cancer Center; UNMC Eppley Cancer Center at The Nebraska Medical Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Aim at Melanoma; Dana-Farber/Brigham and Women's Cancer Center; Vanderbilt-Ingram Cancer Center; Roswell Park Cancer Institute; Moffitt Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Fox Chase Cancer Center; Duke Cancer Institute; The University of Texas MD Anderson Cancer Center; Stanford Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; City of Hope Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; and National Comprehensive Cancer Network.
The NCCN Guidelines for Melanoma provide multidisciplinary recommendations on the clinical management of patients with melanoma. This NCCN Guidelines Insights report highlights notable recent updates. Foremost of these is the exciting addition of the novel agents ipilimumab and vemurafenib for treatment of advanced melanoma. The NCCN panel also included imatinib as a treatment for KIT-mutated tumors and pegylated interferon alfa-2b as an option for adjuvant therapy. Also important are revisions to the initial stratification of early-stage lesions based on the risk of sentinel lymph node metastases, and revised recommendations on the use of sentinel lymph node biopsy for low-risk groups. Finally, the NCCN panel reached clinical consensus on clarifying the role of imaging in the workup of patients with melanoma.