Optimizing Fertility Preservation Practices for Adolescent and Young Adult Cancer Patients

Authors:
Rebecca H. Johnson From Seattle Children’s Hospital, University of Washington, Seattle, Washington.

Search for other papers by Rebecca H. Johnson in
Current site
Google Scholar
PubMed
Close
 MD
and
Leah Kroon From Seattle Children’s Hospital, University of Washington, Seattle, Washington.

Search for other papers by Leah Kroon in
Current site
Google Scholar
PubMed
Close
 MN, RN
Restricted access

Most adolescents and young adults (AYAs) with cancer will survive their disease, and fertility issues are a major concern for this population. The ASCO and new NCCN Clinical Practice Guidelines in Oncology for Adolescent and Young Adult Oncology recommend that oncologists offer the option of fertility preservation to all postpubertal AYAs before the start of potentially gonadotoxic chemotherapy or radiotherapy, providing that the patient does not require emergent start of therapy. Despite the published practice guidelines, many AYAs diagnosed with cancer are still not offered fertility preservation, with oncologists citing lack of time, lack of knowledge, and discomfort in discussing fertility and sexuality with AYAs as reasons. Developing a systematic and coordinated multidisciplinary strategy for fertility preservation referrals within a practice site may streamline the referral process, off-loading some tasks from the oncologist and potentially increasing patient satisfaction, provider satisfaction, and compliance with the guidelines.

Correspondence: Rebecca H. Johnson, MD, Adolescent and Young Adult Oncology Program, Seattle Children’s Hospital, University of Washington, M/S B-6553, PO Box 5371, Seattle, WA 98105-0371. E-mail: rebecca.johnson@seattlechildrens.org
  • Collapse
  • Expand
  • 1

    SEER. Age-distribution of incidence cases. SEER Cancer Statistics Review 1975-2008. Available at: http://seer.cancer.gov/csr/1975_2008/browse_csr.php?section=1&page=sect_01_table.10.html. Accessed November 7, 2011.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2

    Bleyer A, O’Leary M, Barr R, Ries L. Cancer epidemiology in older adolescents and young adults 15 to 29 years of age, including SEER incidence and survival: 1975-2000. NIH Publication No. 06-5767. Bethesda, MD: National Cancer Institute; 2006.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3

    Hudson MM, Landier W, Ganz PA. Impact of survivorship-based research on defining clinical care guidelines. Cancer Epidemiol Biomarkers Prev 2011;20:20852092.

  • 4

    Loi K, Lau M, Loh SF et al.. Attitudes toward fertility preservation in female cancer patients. J Reprod Med 2010;55:411416.

  • 5

    Wallace WH. Oncofertility and preservation of reproductive capacity in children and young adults. Cancer 2011;117(10 Suppl):23012310.

  • 6

    D’Agostino NM, Penney A, Zebrack B. Providing developmentally appropriate psychosocial care to adolescent and young adult cancer survivors. Cancer 2011;117(10 Suppl):23292334.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7

    Levine J, Canada A, Stern CJ. Fertility preservation in adolescents and young adults with cancer. J Clin Oncol 2010;28:48314841.

  • 8

    Lee SJ, Schover LR, Partridge AH et al.. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol 2006;24:29172931.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9

    Ethics Committee of the American Society for Reproductive Medicine. Fertility preservation and reproduction in cancer patients. Fertil Steril 2005;83:16221628.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10

    Fallat ME, Hutter J, American Academy of Pediatrics Committee on Bioethics, American Academy of Pediatrics Section on Hematology/Oncology, American Academy of Pediatrics Section on Surgery. Preservation of fertility in pediatric and adolescent patients with cancer. Pediatrics 2008;121:e14611469.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11

    Coccia PF, Altman J, Bhatia S et al.. NCCN Clinical Practice Guidelines in Oncology: Adolescent and Young Adult (AYA) Oncology. Version 1, 2012. Available at: NCCN.org. Accessed November 10, 2012.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12

    Köhler TS, Kondapalli LA, Shah A et al.. Results from the survey for preservation of adolescent reproduction (SPARE) study: gender disparity in delivery of fertility preservation message to adolescents with cancer. J Assist Reprod Genet 2011;28:269277.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13

    Armuand GM, Rodriguez-Wallberg KA, Wettergren L et al.. Sex differences in fertility-related information received by young adult cancer survivors. J Clin Oncol 2012;30:21472153.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14

    Quinn GP, Vadaparampil ST. Fertility preservation and adolescent/young adult cancer patients: physician communication challenges. J Adolesc Health 2009;44:394400.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15

    Nahata L, Cohen LE, Yu RN. Barriers to fertility preservation in male adolescents with cancer: it’s time for a multidisciplinary approach that includes urologists. Urology 2012;79:12061209.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16

    Shnorhavorian M, Kroon L, Jeffries H, Johnson R. Creating a standardized process to offer the standard of care: continuous process improvement methodology is associated with increased rates of sperm cryopreservation among adolescent and young adult males with cancer. J Pediatr Hematol Oncol 2012;34:e315319.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17

    Sheth KR, Sharma V, Helfand BT et al.. Improved fertility preservation care for male patients with cancer after establishment of formalized oncofertility program. J Urol 2012;187:979986.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18

    LIVESTRONG. Position Statement: Health Insurance Coverage for Iatrogenic Infertility. Available at: http://www.livestrong.org/pdfs/3-0/LIVESTRONG-CLRC-Position-Statement-Iatrogenic-Infe. Accessed November 3, 2011.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19

    Shnorhavorian M, Johnson R, Shear S, Wilfond B. Responding to adolescents with cancer who refuse sperm banking: when “NO” should not be the last word. Journal of Adolescent and Young Adult Oncology 2011;1:114117.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20

    Hsiao W, Stahl PJ, Osterberg EC et al.. Successful treatment of postchemotherapy azoospermia with microsurgical testicular sperm extraction: the Weill Cornell experience. J Clin Oncol 2011;29:16071611.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21

    Dohle GR. Male infertility in cancer patients: review of the literature. Int J Urol 2010;17:327331.

  • 22

    Badawy A. Gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage: prospective randomized study. Fertil Steril 2009;91:694697.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23

    West ER, Zelinski MB, Kondapalli LA et al.. Preserving female fertility following cancer treatment: current options and future possibilities. Pediatr Blood Cancer 2009;53:289295.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24

    Donnez J, Jadoul P, Squifflet J et al.. Ovarian tissue cryopreservation and transplantation in cancer patients. Best Pract Res Clin Obstet Gynaecol 2010;24:87100.

  • 25

    Silber S, Kagawa N, Kuwayama M, Gosden R. Duration of fertility after fresh and frozen ovary transplantation. Fertil Steril 2010;94:21912196.

  • 26

    Sella T, Mironov S, Hricak H. Imaging of transposed ovaries in patients with cervical carcinoma. AJR Am J Roentgenol 2005;184:16021610.

  • 27

    Ginsberg JP, Ogle SK, Tuchman LK et al.. Sperm banking for adolescent and young adult cancer patients: sperm quality, patient, and parent perspectives. Pediatr Blood Cancer 2008;50:594598.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28

    Ginsberg JP, Carlson CA, Lin K et al.. An experimental protocol for fertility preservation in prepubertal boys recently diagnosed with cancer: a report of acceptability and safety. Hum Reprod 2010;25:3741.

    • PubMed
    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 2044 768 97
PDF Downloads 783 177 13
EPUB Downloads 0 0 0