Our Experience With Photodynamic Diagnosis and Photodynamic Therapy for Lung Cancer

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The diagnosis of lung cancer was significantly enhanced by the development of the fiberoptic bronchoscope in 1965. Since then, advances in photosensitizers and light sources have brought photodynamic medicine into the light. This article offers an historic overview of the emergence of photodynamic medicine through the perspective of a pioneer with more than 30 years’ experience. Along with a discussion of photodynamic diagnosis of lung cancers via optical coherence tomography, the curative, palliative, and neoadjuvant roles of photodynamic therapy for early and advanced lung cancers are explored. An emerging strategy of using PDM to treat peripheral early-stage lung tumors is briefly discussed.

Correspondence: Harubumi Kato, MD, PhD, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023 Japan. E-mail: kaharu@gol.com

Dr. Kato is an advisory board member for Medical Proteoscope Co, Ltd, and chairs the Division of Pulmonary Surgery, DPC Committee for the Ministry of Health, Labor, and Welfare in Japan.

  • 1

    Hayata Y, Kato H, Konaka C. Fiberoptic bronchoscopic laser photoradiation for tumor localization in lung cancer. Chest 1982;82:1014.

  • 2

    Kato H, Cortese DA. Early detection of lung cancer by means of hematoporphyrin derivative fluorescence and laser photoradiation. Clin Chest Med 1985;6:237253.

    • Search Google Scholar
    • Export Citation
  • 3

    Lam S, Palcic B, McLean D. Detection of early lung cancer using low dose Photofrin II. Chest 1990;97:333337.

  • 4

    Miyazu Y, Miyazawa T, Kurimoto N. Endobronchial ultrasonography in the assessment of centrally located early-stage lung cancer before photodynamic therapy. Am J Respir Crit Care Med 2002;165:832837.

    • Search Google Scholar
    • Export Citation
  • 5

    Furuse K, Fukuoka M, Kato H. A prospective phase II study on photodynamic therapy with Photofrin II for centrally located early-stage lung cancer. The Japan Lung Cancer Photodynamic Therapy Study Group. J Clin Oncol 1993;11:18521857.

    • Search Google Scholar
    • Export Citation
  • 6

    Kato H, Furukawa K, Sato M. Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung. Lung Cancer 2003;42:103111.

    • Search Google Scholar
    • Export Citation
  • 7

    Simone CB II, Friedberg JS, Glatstein E. Photodynamic therapy for the treatment of non-small cell lung cancer. J Thorac Dis 2011;4:6375.

  • 8

    McCaughan JS Jr, Williams TE Jr, Bethel BH. Photodynamic therapy of endobronchial tumors. Lasers Surg Med 1986;6:336345.

  • 9

    Kato H, Konaka C, Ono J. Preoperative laser photodynamic therapy in combination with operation in lung cancer. J Thorac Cardiovasc Surg 1985;90:420429.

    • Search Google Scholar
    • Export Citation
  • 10

    Okunaka T, Kiyoshi T, Furukawa K. Lung cancers treated with photodynamic therapy and surgery. Diagn Ther Endosc 1999;5:155160.

  • 11

    Johnson BE. Second lung cancers in patients after treatment for an initial lung cancer. J Natl Cancer Inst 1998;90:13351345.

  • 12

    Nakata M, Sawada S, Yamashita M. Surgical treatments for multiple primary adenocarcinoma of the lung. Ann Thorac Surg 2004;78:11941199.

  • 13

    Trousse D, Barlesi F, Loundou A. Synchronous multiple primary lung cancer: an increasing clinical occurrence requiring multidisciplinary management. J Thorac Cardiovasc Surg 2007;133:11931200.

    • Search Google Scholar
    • Export Citation
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