Adolescent and Young Adult Oncology

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Cancer is the leading cause of death among the adolescent and young adult (AYA) population, excluding homicide, suicide, or unintentional injury. AYA patients should be managed by a multidisciplinary team of health care professionals who are well-versed in the specific developmental issues relevant to this patient population. The recommendations for age-appropriate care outlined in these NCCN Guidelines include psychosocial assessment, a discussion of infertility risks associated with treatment and options for fertility preservation, genetic and familial risk assessment for all patients after diagnosis, screening and monitoring of late effects in AYA cancer survivors after successful completion of therapy, and palliative care and end-of-life considerations for patients for whom curative therapy fails.

  • 1

    Bleyer A, O’Leary M, Barr R, Ries L, eds. Cancer epidemiology in older adolescents and young adults 15 to 29 years of age, including SEER incidence and survival: 1975-2000. National Cancer Institute, NIH Pub. No. 06-5767. Bethesda, MD 2006.

    • Search Google Scholar
    • Export Citation
  • 2

    Burke ME, Albritton K, Marina N. Challenges in the recruitment of adolescents and young adults to cancer clinical trials. Cancer 2007;110:23852393.

    • Search Google Scholar
    • Export Citation
  • 3

    Ferrari A, Montello M, Budd T, Bleyer A. The challenges of clinical trials for adolescents and young adults with cancer. Pediatr Blood Cancer 2008;50:11011104.

    • Search Google Scholar
    • Export Citation
  • 4

    Bleyer A, Budd T, Montello M. Adolescents and young adults with cancer: the scope of the problem and criticality of clinical trials. Cancer 2006;107:16451655.

    • Search Google Scholar
    • Export Citation
  • 5

    Bleyer A. Young adult oncology: the patients and their survival challenges. CA Cancer J Clin 2007;57:242255.

  • 6

    Bleyer A, Barr R, Hayes-Lattin B. The distinctive biology of cancer in adolescents and young adults. Nat Rev Cancer 2008;8:288298.

  • 7

    Ramphal R, Meyer R, Schacter B. Active therapy and models of care for adolescents and young adults with cancer. Cancer 2011;117:23162322.

  • 8

    Closing the gap: research and care imperatives for adolescents and young adults with cancer: report of the adolescent and young adult oncology progress review group. Available at: http://planning.cancer.gov/library/AYAO_PRG_Report_2006_FINAL.pdf. Accessed July 25, 2012.

    • Search Google Scholar
    • Export Citation
  • 9

    Bleyer A, Viny A, Barr R. Cancer in 15- to 29-year-olds by primary site. Oncologist 2006;11:590601.

  • 10

    Howlader N, Noone AM, Krapcho M. SEER Cancer Statistics Review, 1975-2008, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2008/, based on November 2010 SEER data submission, posted to the SEER web site, 2011.

    • Search Google Scholar
    • Export Citation
  • 11

    Zebrack B, Mathews-Bradshaw B, Siegel S. Quality cancer care for adolescents and young adults: a position statement. J Clin Oncol 2010;28:48624867.

    • Search Google Scholar
    • Export Citation
  • 12

    Alman BA, Pajerski ME, Diaz-Cano S. Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder. Diagn Mol Pathol 1997;6:98101.

  • 13

    Abramson DH, Ellsworth RM, Kitchin FD, Tung G. Second nonocular tumors in retinoblastoma survivors. Are they radiation-induced? Ophthalmology 1984;91:13511355.

    • Search Google Scholar
    • Export Citation
  • 14

    Malkin D, Li FP, Strong LC. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990;250:12331238.

    • Search Google Scholar
    • Export Citation
  • 15

    Miettinen M, Wang ZF, Sarlomo-Rikala M. Succinate dehydrogenase-deficient GISTs: a clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age. Am J Surg Pathol 2011;35:17121721.

    • Search Google Scholar
    • Export Citation
  • 16

    Janeway KA, Kim SY, Lodish M. Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. Proc Natl Acad Sci U S A 2011;108:314318.

    • Search Google Scholar
    • Export Citation
  • 17

    Friedman JM. Neurofibromatosis 1. In: Pagon RA, Bird TD, Dolan CR, Stephens K, eds. GeneReviews [Internet]. Seattle, WA: University of Washington; 1993–1998. Initial Posting: October 2, 1998; Last Update: June 2, 2009.

    • Search Google Scholar
    • Export Citation
  • 18

    Smith RA, Cokkinides V, Brooks D. Cancer screening in the United States, 2010: a review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin 2010;60:99119.

    • Search Google Scholar
    • Export Citation
  • 19

    Bryant H. Screening for cancer in children, adolescents, and young adults: questions and more questions. Cancer 2011;117:22752280.

  • 20

    Pollock BH, Krischer JP, Vietti TJ. Interval between symptom onset and diagnosis of pediatric solid tumors. J Pediatr 1991;119:725732.

  • 21

    Klein-Geltink J, Pogany L, Mery LS. Impact of age and diagnosis on waiting times between important healthcare events among children 0 to 19 years cared for in pediatric units: the Canadian Childhood Cancer Surveillance and Control Program. J Pediatr Hematol Oncol 2006;28:433439.

    • Search Google Scholar
    • Export Citation
  • 22

    Dang-Tan T, Trottier H, Mery LS. Delays in diagnosis and treatment among children and adolescents with cancer in Canada. Pediatr Blood Cancer 2008;51:468474.

    • Search Google Scholar
    • Export Citation
  • 23

    Martin S, Ulrich C, Munsell M. Delays in cancer diagnosis in underinsured young adults and older adolescents. Oncologist 2007;12:816824.

  • 24

    Ferrari A, Thomas D, Franklin AR. Starting an adolescent and young adult program: some success stories and some obstacles to overcome. J Clin Oncol 2010;28:48504857.

    • Search Google Scholar
    • Export Citation
  • 25

    Boissel N, Auclerc MF, Lheritier V. Should adolescents with acute lymphoblastic leukemia be treated as old children or young adults? Comparison of the French FRALLE-93 and LALA-94 trials. J Clin Oncol 2003;21:774780.

    • Search Google Scholar
    • Export Citation
  • 26

    de Bont JM, Holt Bvd, Dekker AW. Significant difference in outcome for adolescents with acute lymphoblastic leukemia treated on pediatric vs adult protocols in the Netherlands. Leukemia 2004;18:20322035.

    • Search Google Scholar
    • Export Citation
  • 27

    Ribera JM, Oriol A, Sanz MA. Comparison of the results of the treatment of adolescents and young adults with standard-risk acute lymphoblastic leukemia with the Programa Espanol de Tratamiento en Hematologia pediatric-based protocol ALL-96. J Clin Oncol 2008;26:18431849.

    • Search Google Scholar
    • Export Citation
  • 28

    Stock W, La M, Sanford B. What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children’s Cancer Group and Cancer and Leukemia Group B studies. Blood 2008;112:16461654.

    • Search Google Scholar
    • Export Citation
  • 29

    Huguet F, Leguay T, Raffoux E. Pediatric-inspired therapy in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: the GRAALL-2003 study. J Clin Oncol 2009;27:911918.

    • Search Google Scholar
    • Export Citation
  • 30

    Ferrari A, Dileo P, Casanova M. Rhabdomyosarcoma in adults. A retrospective analysis of 171 patients treated at a single institution. Cancer 2003;98:571580.

    • Search Google Scholar
    • Export Citation
  • 31

    Scurr M, Judson I. How to treat the Ewing’s family of sarcomas in adult patients. Oncologist 2006;11:6572.

  • 32

    Sandlund JT. Should adolescents with NHL be treated as old children or young adults? Hematology Am Soc Hematol Educ Program 2007:297303.

    • Search Google Scholar
    • Export Citation
  • 33

    Tai E, Pollack LA, Townsend J. Differences in non-Hodgkin lymphoma survival between young adults and children. Arch Pediatr Adolesc Med 2010;164:218224.

    • Search Google Scholar
    • Export Citation
  • 34

    Burkhardt B, Oschlies I, Klapper W. Non-Hodgkin’s lymphoma in adolescents: experiences in 378 adolescent NHL patients treated according to pediatric NHL-BFM protocols. Leukemia 2011;25:153160.

    • Search Google Scholar
    • Export Citation
  • 35

    Bleyer WA, Tejeda H, Murphy SB. National cancer clinical trials: children have equal access; adolescents do not. J Adolesc Health 1997;21:366373.

    • Search Google Scholar
    • Export Citation
  • 36

    Shochat SJ, Fremgen AM, Murphy SB. Childhood cancer: patterns of protocol participation in a national survey. CA Cancer J Clin 2001;51:119130.

    • Search Google Scholar
    • Export Citation
  • 37

    Downs-Canner S, Shaw PH. A comparison of clinical trial enrollment between adolescent and young adult (AYA) oncology patients treated at affiliated adult and pediatric oncology centers. J Pediatr Hematol Oncol 2009;31:927929.

    • Search Google Scholar
    • Export Citation
  • 38

    Parsons HM, Harlan LC, Seibel NL. Clinical trial participation and time to treatment among adolescents and young adults with cancer: does age at diagnosis or insurance make a difference? J Clin Oncol 2011;29:40454053.

    • Search Google Scholar
    • Export Citation
  • 39

    Howell DL, Ward KC, Austin HD. Access to pediatric cancer care by age, race, and diagnosis, and outcomes of cancer treatment in pediatric and adolescent patients in the state of Georgia. J Clin Oncol 2007;25:46104615.

    • Search Google Scholar
    • Export Citation
  • 40

    Albritton KH, Wiggins CH, Nelson HE, Weeks JC. Site of oncologic specialty care for older adolescents in Utah. J Clin Oncol 2007;25:46164621.

  • 41

    Bleyer A. The Quid Pro Quo of pediatric versus adult services for older adolescent cancer patients. Pediatr Blood Cancer 2010;54:238241.

    • Search Google Scholar
    • Export Citation
  • 42

    Veal GJ, Hartford CM, Stewart CF. Clinical pharmacology in the adolescent oncology patient. J Clin Oncol 2010;28:47904799.

  • 43

    Oeffinger KC, Mertens AC, Hudson MM. Health care of young adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Ann Fam Med 2004;2:6170.

    • Search Google Scholar
    • Export Citation
  • 44

    Oeffinger KC, Hudson MM. Long-term complications following childhood and adolescent cancer: foundations for providing risk-based health care for survivors. CA Cancer J Clin 2004;54:208236.

    • Search Google Scholar
    • Export Citation
  • 45

    Armstrong GT, Stovall M, Robison LL. Long-term effects of radiation exposure among adult survivors of childhood cancer: results from the childhood cancer survivor study. Radiat Res 2010;174:840850.

    • Search Google Scholar
    • Export Citation
  • 46

    Levine J, Canada A, Stern CJ. Fertility preservation in adolescents and young adults with cancer. J Clin Oncol 2010;28:48314841.

  • 47

    Janson C, Leisenring W, Cox C. Predictors of marriage and divorce in adult survivors of childhood cancers: a report from the Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev 2009;18:26262635.

    • Search Google Scholar
    • Export Citation
  • 48

    Bleyer A, Choi M, Wang SJ. Increased vulnerability of the spinal cord to radiation or intrathecal chemotherapy during adolescence: a report from the Children’s Oncology Group. Pediatr Blood Cancer 2009;53:12051210.

    • Search Google Scholar
    • Export Citation
  • 49

    Hijiya N, Ness KK, Ribeiro RC, Hudson MM. Acute leukemia as a secondary malignancy in children and adolescents: current findings and issues. Cancer 2009;115:2335.

    • Search Google Scholar
    • Export Citation
  • 50

    Knight KR, Kraemer DF, Neuwelt EA. Ototoxicity in children receiving platinum chemotherapy: underestimating a commonly occurring toxicity that may influence academic and social development. J Clin Oncol 2005;23:85888596.

    • Search Google Scholar
    • Export Citation
  • 51

    Schell MJ, McHaney VA, Green AA. Hearing loss in children and young adults receiving cisplatin with or without prior cranial irradiation. J Clin Oncol 1989;7:754760.

    • Search Google Scholar
    • Export Citation
  • 52

    Skinner R, Cotterill SJ, Stevens MC. Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study. United Kingdom Children’s Cancer Study Group. Br J Cancer 2000;82:16361645.

    • Search Google Scholar
    • Export Citation
  • 53

    Roscoe JA, Morrow GR, Aapro MS. Anticipatory nausea and vomiting. Support Care Cancer 2011;19:15331538.

  • 54

    Figueroa-Moseley C, Jean-Pierre P, Roscoe JA. Behavioral interventions in treating anticipatory nausea and vomiting. J Natl Compr Canc Netw 2007;5:4450.

    • Search Google Scholar
    • Export Citation
  • 55

    Armenian SH, Sun CL, Kawashima T. Long-term health-related outcomes in survivors of childhood cancer treated with hematopoietic cell transplantation (HCT) versus conventional therapy: a report from the Bone Marrow Transplant Survivor Study (BMTSS) and Childhood Cancer Survivor Study (CCSS). Blood 2011;118:14131420.

    • Search Google Scholar
    • Export Citation
  • 56

    Rizzo JD, Curtis RE, Socie G. Solid cancers after allogeneic hematopoietic cell transplantation. Blood 2009;113:11751183.

  • 57

    Wallace WH. Oncofertility and preservation of reproductive capacity in children and young adults. Cancer 2011;117:23012310.

  • 58

    Lee SJ, Schover LR, Partridge AH. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol 2006;24:29172931.

    • Search Google Scholar
    • Export Citation
  • 59

    Wallace WH, Anderson RA, Irvine DS. Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet Oncol 2005;6:209218.

    • Search Google Scholar
    • Export Citation
  • 60

    Darzy KH. Radiation-induced hypopituitarism after cancer therapy: who, how and when to test. Nat Clin Pract Endocrinol Metab 2009;5:8899.

    • Search Google Scholar
    • Export Citation
  • 61

    Redig AJ, Brannigan R, Stryker SJ. Incorporating fertility preservation into the care of young oncology patients. Cancer 2011;117:410.

  • 62

    Green DM, Kawashima T, Stovall M. Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study. J Clin Oncol 2009;27:26772685.

    • Search Google Scholar
    • Export Citation
  • 63

    Green DM, Nolan VG, Kawashima T. Decreased fertility among female childhood cancer survivors who received 22-27 Gy hypothalamic/pituitary irradiation: a report from the Childhood Cancer Survivor Study. Fertil Steril 2011;95:1922–1927, 1927 e1921.

    • Search Google Scholar
    • Export Citation
  • 64

    Chemaitilly W, Mertens AC, Mitby P. Acute ovarian failure in the childhood cancer survivor study. J Clin Endocrinol Metab 2006;91:17231728.

  • 65

    Green DM, Sklar CA, Boice JD Jr. Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study. J Clin Oncol 2009;27:23742381.

    • Search Google Scholar
    • Export Citation
  • 66

    Wo JY, Viswanathan AN. Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients. Int J Radiat Oncol Biol Phys 2009;73:13041312.

    • Search Google Scholar
    • Export Citation
  • 67

    Lobo RA. Potential options for preservation of fertility in women. N Engl J Med 2005;353:6473.

  • 68

    Bines J, Oleske DM, Cobleigh MA. Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol 1996;14:17181729.

    • Search Google Scholar
    • Export Citation
  • 69

    Goodwin PJ, Ennis M, Pritchard KI. Risk of menopause during the first year after breast cancer diagnosis. J Clin Oncol 1999;17:23652370.

  • 70

    De Bruin ML, Huisbrink J, Hauptmann M. Treatment-related risk factors for premature menopause following Hodgkin lymphoma. Blood 2008;111:101108.

    • Search Google Scholar
    • Export Citation
  • 71

    Haukvik UKH, Dieset I, Bjoro T. Treatment-related premature ovarian failure as a long-term complication after Hodgkin’s lymphoma. Ann Oncol 2006;17:14281433.

    • Search Google Scholar
    • Export Citation
  • 72

    Terenziani M, Piva L, Meazza C. Oophoropexy: a relevant role in preservation of ovarian function after pelvic irradiation. Fertil Steril 2009;91:935, e915–936.

    • Search Google Scholar
    • Export Citation
  • 73

    Badawy A, Elnashar A, El-Ashry M, Shahat M. Gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage: prospective randomized study. Fertil Steril 2009;91:694697.

    • Search Google Scholar
    • Export Citation
  • 74

    Behringer K, Wildt L, Mueller H. No protection of the ovarian follicle pool with the use of GnRH-analogues or oral contraceptives in young women treated with escalated BEACOPP for advanced-stage Hodgkin lymphoma. Final results of a phase II trial from the German Hodgkin Study Group. Ann Oncol 2010;21:20522060.

    • Search Google Scholar
    • Export Citation
  • 75

    Bedaiwy MA, Abou-Setta AM, Desai N. Gonadotropin-releasing hormone analog cotreatment for preservation of ovarian function during gonadotoxic chemotherapy: a systematic review and meta-analysis. Fertil Steril 2011;95:906–914, e901–904.

    • Search Google Scholar
    • Export Citation
  • 76

    Azim H Jr, Gentilini O, Locatelli M. Managing pregnant women with cancer: personal considerations and a review of the literature. Ecancermedicalscience 2011;5:204.

    • Search Google Scholar
    • Export Citation
  • 77

    Azim HA Jr, Pavlidis N, Peccatori FA. Treatment of the pregnant mother with cancer: a systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part II: Hematological tumors. Cancer Treat Rev 2010;36:110121.

    • Search Google Scholar
    • Export Citation
  • 78

    Azim HA Jr, Peccatori FA, Pavlidis N. Treatment of the pregnant mother with cancer: a systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part I: Solid tumors. Cancer Treat Rev 2010;36:101109.

    • Search Google Scholar
    • Export Citation
  • 79

    Chemaitilly W, Sklar CA. Endocrine complications in long-term survivors of childhood cancers. Endocr Relat Cancer 2010;17:R141159.

  • 80

    Kenney LB, Laufer MR, Grant FD. High risk of infertility and long term gonadal damage in males treated with high dose cyclophosphamide for sarcoma during childhood. Cancer 2001;91:613621.

    • Search Google Scholar
    • Export Citation
  • 81

    Lee SJ, Schover LR, Partridge AH. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol 2006;24:29172931.

    • Search Google Scholar
    • Export Citation
  • 82

    Zebrack BJ. Psychological, social, and behavioral issues for young adults with cancer. Cancer 2011;117:22892294.

  • 83

    Abrams AN, Hazen EP, Penson RT. Psychosocial issues in adolescents with cancer. Cancer Treat Rev 2007;33:622630.

  • 84

    Zebrack B, Isaacson S. Psychosocial care of adolescent and young adult patients with cancer and survivors. J Clin Oncol 2012;30:12211226.

    • Search Google Scholar
    • Export Citation
  • 85

    D’Agostino NM, Penney A, Zebrack B. Providing developmentally appropriate psychosocial care to adolescent and young adult cancer survivors. Cancer 2011;117:23292334.

    • Search Google Scholar
    • Export Citation
  • 86

    Zeltzer LK. Cancer in adolescents and young adults psychosocial aspects. Long-term survivors. Cancer 1993;71:34633468.

  • 87

    Arnett JJ. Emerging adulthood. A theory of development from the late teens through the twenties. Am Psychol 2000;55:469480.

  • 88

    Morgan S, Davies S, Palmer S, Plaster M. Sex, drugs, and rock ‘n’ roll: caring for adolescents and young adults with cancer. J Clin Oncol 2010;28:48254830.

    • Search Google Scholar
    • Export Citation
  • 89

    Vinokur AD, Threatt BA, Vinokur-Kaplan D, Satariano WA. The process of recovery from breast cancer for younger and older patients. Changes during the first year. Cancer 1990;65:12421254.

    • Search Google Scholar
    • Export Citation
  • 90

    Mor V, Allen S, Malin M. The psychosocial impact of cancer on older versus younger patients and their families. Cancer 1994;74:21182127.

  • 91

    Stava CJ, Lopez A, Vassilopoulou-Sellin R. Health profiles of younger and older breast cancer survivors. Cancer 2006;107:17521759.

  • 92

    Kazak AE, Derosa BW, Schwartz LA. Psychological outcomes and health beliefs in adolescent and young adult survivors of childhood cancer and controls. J Clin Oncol 2010;28:20022007.

    • Search Google Scholar
    • Export Citation
  • 93

    Krull KR, Huang S, Gurney JG. Adolescent behavior and adult health status in childhood cancer survivors. J Cancer Surviv 2010;4:210217.

  • 94

    Emmons K, Li FP, Whitton J. Predictors of smoking initiation and cessation among childhood cancer survivors: a report from the childhood cancer survivor study. J Clin Oncol 2002;20:16081616.

    • Search Google Scholar
    • Export Citation
  • 95

    Lown EA, Goldsby R, Mertens AC. Alcohol consumption patterns and risk factors among childhood cancer survivors compared to siblings and general population peers. Addiction 2008;103:11391148.

    • Search Google Scholar
    • Export Citation
  • 96

    Cox CL, McLaughlin RA, Steen BD, Hudson MM. Predicting and modifying substance use in childhood cancer survivors: application of a conceptual model. Oncol Nurs Forum 2006;33:5160.

    • Search Google Scholar
    • Export Citation
  • 97

    Zebrack B, Bleyer A, Albritton K. Assessing the health care needs of adolescent and young adult cancer patients and survivors. Cancer 2006;107:29152923.

    • Search Google Scholar
    • Export Citation
  • 98

    Palefsky JM, Giuliano AR, Goldstone S. HPV vaccine against anal HPV infection and anal intraepithelial neoplasia. N Engl J Med 2011;365:15761585.

    • Search Google Scholar
    • Export Citation
  • 99

    Butow P, Palmer S, Pai A. Review of adherence-related issues in adolescents and young adults with cancer. J Clin Oncol 2010;28:48004809.

  • 100

    Kondryn HJ, Edmondson CL, Hill J, Eden TO. Treatment non-adherence in teenage and young adult patients with cancer. Lancet Oncol 2011;12:100108.

    • Search Google Scholar
    • Export Citation
  • 101

    Windebank KP, Spinetta JJ. Do as I say or die: compliance in adolescents with cancer. Pediatr Blood Cancer 2008;50:10991100.

  • 102

    Kato PM, Cole SW, Bradlyn AS, Pollock BH. A video game improves behavioral outcomes in adolescents and young adults with cancer: a randomized trial. Pediatrics 2008;122:e305317.

    • Search Google Scholar
    • Export Citation
  • 103

    Kahana S, Drotar D, Frazier T. Meta-analysis of psychological interventions to promote adherence to treatment in pediatric chronic health conditions. J Pediatr Psychol 2008;33:590611.

    • Search Google Scholar
    • Export Citation
  • 104

    Albritton K, Barr R, Bleyer A. The adolescence of young adult oncology. Semin Oncol 2009;36:478488.

  • 105

    Kyngas H, Mikkonen R, Nousiainen EM. Coping with the onset of cancer: coping strategies and resources of young people with cancer. Eur J Cancer Care (Engl) 2001;10:611.

    • Search Google Scholar
    • Export Citation
  • 106

    Zebrack BJ, Oeffinger KC, Hou P, Kaplan S. Advocacy skills training for young adult cancer survivors: the Young Adult Survivors Conference at Camp Mak-a-Dream. Support Care Cancer 2006;14:779782.

    • Search Google Scholar
    • Export Citation
  • 107

    Treadgold CL, Kuperberg A. Been there, done that, wrote the blog: the choices and challenges of supporting adolescents and young adults with cancer. J Clin Oncol 2010;28:48424849.

    • Search Google Scholar
    • Export Citation
  • 108

    Zebrack B. Information and service needs for young adult cancer patients. Support Care Cancer 2008;16:13531360.

  • 109

    Zebrack B. Information and service needs for young adult cancer survivors. Support Care Cancer 2009;17:349357.

  • 110

    Palmer S, Mitchell A, Thompson K, Sexton M. Unmet needs among adolescent cancer patients: a pilot study. Palliat Support Care 2007;5:127134.

  • 111

    Fallon S, Smith J, Morgan S. ‘Pizza, patients and points of view’: involving young people in the design of a post registration module entitled the adolescent with cancer. Nurse Educ Pract 2008;8:140147.

    • Search Google Scholar
    • Export Citation
  • 112

    Rabin C, Simpson N, Morrow K, Pinto B. Behavioral and psychosocial program needs of young adult cancer survivors. Qual Health Res 2011;21:796806.

    • Search Google Scholar
    • Export Citation
  • 113

    Kirchhoff AC, Leisenring W, Krull KR. Unemployment among adult survivors of childhood cancer: a report from the childhood cancer survivor study. Med Care 2010;48:10151025.

    • Search Google Scholar
    • Export Citation
  • 114

    Zeltzer LK, Recklitis C, Buchbinder D. Psychological status in childhood cancer survivors: a report from the Childhood Cancer Survivor Study. J Clin Oncol 2009;27:23962404.

    • Search Google Scholar
    • Export Citation
  • 115

    Soliman H, Agresta SV. Current issues in adolescent and young adult cancer survivorship. Cancer Control 2008;15:5562.

  • 116

    Oeffinger KC, Tonorezos ES. The cancer is over, now what?: Understanding risk, changing outcomes. Cancer 2011;117:22502257.

  • 117

    Woodward E, Jessop M, Glaser A, Stark D. Late effects in survivors of teenage and young adult cancer: does age matter? Ann Oncol 2011;22:25612568.

    • Search Google Scholar
    • Export Citation
  • 118

    Oeffinger KC, Mertens AC, Sklar CA. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 2006;355:15721582.

  • 119

    Armstrong GT, Liu Q, Yasui Y. Late mortality among 5-year survivors of childhood cancer: a summary from the Childhood Cancer Survivor Study. J Clin Oncol 2009;27:23282338.

    • Search Google Scholar
    • Export Citation
  • 120

    Dores GM, Metayer C, Curtis RE. Second malignant neoplasms among long-term survivors of Hodgkin’s disease: a population-based evaluation over 25 years. J Clin Oncol 2002;20:34843494.

    • Search Google Scholar
    • Export Citation
  • 121

    Aleman BM, van den Belt-Dusebout AW, De Bruin ML. Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood 2007;109:18781886.

  • 122

    Curtis RE, Freedman DM, Ron E, et al, eds. New malignancies among cancer survivors: SEER Cancer Registries, 1973–2000. National Cancer Institute, NIH Publ. No. 05-5302. Bethesda, MD, 2006.

    • Search Google Scholar
    • Export Citation
  • 123

    Ng AK, Travis LB. Subsequent malignant neoplasms in cancer survivors. Cancer J 2008;14:429434.

  • 124

    Ng AK, Kenney LB, Gilbert ES, Travis LB. Secondary malignancies across the age spectrum. Semin Radiat Oncol 2010;20:6778.

  • 125

    Friedman DL, Whitton J, Leisenring W. Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. J Natl Cancer Inst 2010;102:10831095.

    • Search Google Scholar
    • Export Citation
  • 126

    Meadows AT, Friedman DL, Neglia JP. Second neoplasms in survivors of childhood cancer: findings from the Childhood Cancer Survivor Study cohort. J Clin Oncol 2009;27:23562362.

    • Search Google Scholar
    • Export Citation
  • 127

    Travis LB, Hill DA, Dores GM. Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease. JAMA 2003;290:465475.

    • Search Google Scholar
    • Export Citation
  • 128

    van Leeuwen FE, Klokman WJ, Stovall M. Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin’s disease. J Natl Cancer Inst 2003;95:971980.

    • Search Google Scholar
    • Export Citation
  • 129

    Travis LB, Hill D, Dores GM. Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma. J Natl Cancer Inst 2005;97:14281437.

    • Search Google Scholar
    • Export Citation
  • 130

    Henderson TO, Amsterdam A, Bhatia S. Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer. Ann Intern Med 2010;152:444–455; W144–454.

    • Search Google Scholar
    • Export Citation
  • 131

    Travis LB, Gospodarowicz M, Curtis RE. Lung cancer following chemotherapy and radiotherapy for Hodgkin’s disease. J Natl Cancer Inst 2002;94:182192.

    • Search Google Scholar
    • Export Citation
  • 132

    Swerdlow AJ, Higgins CD, Smith P. Second cancer risk after chemotherapy for Hodgkin’s lymphoma: a collaborative British cohort study. J Clin Oncol 2011;29:40964104.

    • Search Google Scholar
    • Export Citation
  • 133

    Travis LB, Beard C, Allan JM. Testicular cancer survivorship: research strategies and recommendations. J Natl Cancer Inst 2010;102:11141130.

    • Search Google Scholar
    • Export Citation
  • 134

    Gilligan T. Testicular cancer survivorship. Hematol Oncol Clin North Am 2011;25:627–639, x.

  • 135

    Fossa SD, Chen J, Schonfeld SJ. Risk of contralateral testicular cancer: a population-based study of 29,515 U.S. men. J Natl Cancer Inst 2005;97:10561066.

    • Search Google Scholar
    • Export Citation
  • 136

    Travis LB, Fossa SD, Schonfeld SJ. Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. J Natl Cancer Inst 2005;97:13541365.

    • Search Google Scholar
    • Export Citation
  • 137

    Wierecky J, Kollmannsberger C, Boehlke I. Secondary leukemia after first-line high-dose chemotherapy for patients with advanced germ cell cancer. J Cancer Res Clin Oncol 2005;131:255260.

    • Search Google Scholar
    • Export Citation
  • 138

    Howard R, Gilbert E, Lynch CF. Risk of leukemia among survivors of testicular cancer: a population-based study of 42,722 patients. Ann Epidemiol 2008;18:416421.

    • Search Google Scholar
    • Export Citation
  • 139

    Chaturvedi AK, Engels EA, Gilbert ES. Second cancers among 104,760 survivors of cervical cancer: evaluation of long-term risk. J Natl Cancer Inst 2007;99:16341643.

    • Search Google Scholar
    • Export Citation
  • 140

    Brown LM, Chen BE, Pfeiffer RM. Risk of second non-hematological malignancies among 376,825 breast cancer survivors. Breast Cancer Res Treat 2007;106:439451.

    • Search Google Scholar
    • Export Citation
  • 141

    Hemminki K, Lenner P, Sundquist J, Bermejo JL. Risk of subsequent solid tumors after non-Hodgkin’s lymphoma: effect of diagnostic age and time since diagnosis. J Clin Oncol 2008;26:18501857.

    • Search Google Scholar
    • Export Citation
  • 142

    Ginsberg JP, Goodman P, Leisenring W. Long-term survivors of childhood Ewing sarcoma: report from the childhood cancer survivor study. J Natl Cancer Inst 2010;102:12721283.

    • Search Google Scholar
    • Export Citation
  • 143

    Nagarajan R, Kamruzzaman A, Ness KK. Twenty years of follow-up of survivors of childhood osteosarcoma: a report from the Childhood Cancer Survivor Study. Cancer 2011;117:625634.

    • Search Google Scholar
    • Export Citation
  • 144

    Children’s Oncology Group. Long-term follow-up guidelines for survivors of childhood, adolescent and young adult cancers, Version 3.0; 2008.

    • Search Google Scholar
    • Export Citation
  • 145

    Chen MH, Colan SD, Diller L. Cardiovascular disease: cause of morbidity and mortality in adult survivors of childhood cancers. Circ Res 2011;108:619628.

    • Search Google Scholar
    • Export Citation
  • 146

    Reinders JG, Heijmen BJ, Olofsen-van Acht MJ. Ischemic heart disease after mantlefield irradiation for Hodgkin’s disease in long-term follow-up. Radiother Oncol 1999;51:3542.

    • Search Google Scholar
    • Export Citation
  • 147

    Swerdlow AJ, Higgins CD, Smith P. Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study. J Natl Cancer Inst 2007;99:206214.

    • Search Google Scholar
    • Export Citation
  • 148

    van den Belt-Dusebout AW, Nuver J, de Wit R. Long-term risk of cardiovascular disease in 5-year survivors of testicular cancer. J Clin Oncol 2006;24:467475.

    • Search Google Scholar
    • Export Citation
  • 149

    Haugnes HS, Wethal T, Aass N. Cardiovascular risk factors and morbidity in long-term survivors of testicular cancer: a 20-year follow-up study. J Clin Oncol 2010;28:46494657.

    • Search Google Scholar
    • Export Citation
  • 150

    Abouassaly R, Fossa SD, Giwercman A. Sequelae of treatment in long-term survivors of testis cancer. Eur Urol 2011;60:516526.

  • 151

    Mulrooney DA, Yeazel MW, Kawashima T. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ 2009;339:b4606.

    • Search Google Scholar
    • Export Citation
  • 152

    Mertens AC, Yasui Y, Liu Y. Pulmonary complications in survivors of childhood and adolescent cancer. A report from the Childhood Cancer Survivor Study. Cancer 2002;95:24312441.

    • Search Google Scholar
    • Export Citation
  • 153

    Fossa SD, Gilbert E, Dores GM. Noncancer causes of death in survivors of testicular cancer. J Natl Cancer Inst 2007;99:533544.

  • 154

    O’Sullivan JM, Huddart RA, Norman AR. Predicting the risk of bleomycin lung toxicity in patients with germ-cell tumours. Ann Oncol 2003;14:9196.

    • Search Google Scholar
    • Export Citation
  • 155

    Haugnes HS, Aass N, Fossa SD. Pulmonary function in long-term survivors of testicular cancer. J Clin Oncol 2009;27:27792786.

  • 156

    Diller L, Chow EJ, Gurney JG. Chronic disease in the Childhood Cancer Survivor Study cohort: a review of published findings. J Clin Oncol 2009;27:23392355.

    • Search Google Scholar
    • Export Citation
  • 157

    Packer RJ, Gurney JG, Punyko JA. Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor study. J Clin Oncol 2003;21:32553261.

    • Search Google Scholar
    • Export Citation
  • 158

    Brydoy M, Oldenburg J, Klepp O. Observational study of prevalence of long-term Raynaud-like phenomena and neurological side effects in testicular cancer survivors. J Natl Cancer Inst 2009;101:16821695.

    • Search Google Scholar
    • Export Citation
  • 159

    Bowers DC, McNeil DE, Liu Y. Stroke as a late treatment effect of Hodgkin’s disease: a report from the Childhood Cancer Survivor Study. J Clin Oncol 2005;23:65086515.

    • Search Google Scholar
    • Export Citation
  • 160

    Bowers DC, Liu Y, Leisenring W. Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study. J Clin Oncol 2006;24:52775282.

    • Search Google Scholar
    • Export Citation
  • 161

    De Bruin ML, Dorresteijn LD, van’t Veer MB. Increased risk of stroke and transient ischemic attack in 5-year survivors of Hodgkin lymphoma. J Natl Cancer Inst 2009;101:928937.

    • Search Google Scholar
    • Export Citation
  • 162

    Chow EJ, Friedman DL, Stovall M. Risk of thyroid dysfunction and subsequent thyroid cancer among survivors of acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Pediatr Blood Cancer 2009;53:432437.

    • Search Google Scholar
    • Export Citation
  • 163

    Bhatti P, Veiga LH, Ronckers CM. Risk of second primary thyroid cancer after radiotherapy for a childhood cancer in a large cohort study: an update from the childhood cancer survivor study. Radiat Res 2010;174:741752.

    • Search Google Scholar
    • Export Citation
  • 164

    Huddart RA, Norman A, Moynihan C. Fertility, gonadal and sexual function in survivors of testicular cancer. Br J Cancer 2005;93:200207.

  • 165

    Shankar SM, Marina N, Hudson MM. Monitoring for cardiovascular disease in survivors of childhood cancer: report from the Cardiovascular Disease Task Force of the Children’s Oncology Group. Pediatrics 2008;121:e387396.

    • Search Google Scholar
    • Export Citation
  • 166

    Liles A, Blatt J, Morris D. Monitoring pulmonary complications in long-term childhood cancer survivors: guidelines for the primary care physician. Cleve Clin J Med 2008;75:531539.

    • Search Google Scholar
    • Export Citation
  • 167

    Freyer DR. Transition of care for young adult survivors of childhood and adolescent cancer: rationale and approaches. J Clin Oncol 2010;28:48104818.

    • Search Google Scholar
    • Export Citation
  • 168

    Nathan PC, Hayes-Lattin B, Sisler JJ, Hudson MM. Critical issues in transition and survivorship for adolescents and young adults with cancers. Cancer 2011;117:23352341.

    • Search Google Scholar
    • Export Citation
  • 169

    Oeffinger KC, McCabe MS. Models for delivering survivorship care. J Clin Oncol 2006;24:51175124.

  • 170

    Snyder CF, Earle CC, Herbert RJ. Preventive care for colorectal cancer survivors: a 5-year longitudinal study. J Clin Oncol 2008;26:10731079.

    • Search Google Scholar
    • Export Citation
  • 171

    Snyder CF, Frick KD, Kantsiper ME. Prevention, screening, and surveillance care for breast cancer survivors compared with controls: changes from 1998 to 2002. J Clin Oncol 2009;27:10541061.

    • Search Google Scholar
    • Export Citation
  • 172

    Blaauwbroek R, Tuinier W, Meyboom-de Jong B. Shared care by paediatric oncologists and family doctors for long-term follow-up of adult childhood cancer survivors: a pilot study. Lancet Oncol 2008;9:232238.

    • Search Google Scholar
    • Export Citation
  • 173

    Wallace WH, Blacklay A, Eiser C. Developing strategies for long term follow up of survivors of childhood cancer. BMJ 2001;323:271274.

  • 174

    Oeffinger KC. Longitudinal risk-based health care for adult survivors of childhood cancer. Curr Probl Cancer 2003;27:143167.

  • 175

    Wein S, Pery S, Zer A. Role of palliative care in adolescent and young adult oncology. J Clin Oncol 2010;28:48194824.

  • 176

    Pritchard S, Cuvelier G, Harlos M, Barr R. Palliative care in adolescents and young adults with cancer. Cancer 2011;117:23232328.

  • 177

    Lyon ME, McCabe MA, Patel KM, D’Angelo LJ. What do adolescents want? An exploratory study regarding end-of-life decision-making. J Adolesc Health 2004;35:529, e521–526.

    • Search Google Scholar
    • Export Citation
  • 178

    Webb NM, Tucker D. Young adults’ opinions about hospice and home death. J Palliat Med 2009;12:337342.

  • 179

    Bell CJ, Skiles J, Pradhan K, Champion VL. End-of-life experiences in adolescents dying with cancer. Support Care Cancer 2010;18:827835.

  • 180

    Wiener L, Ballard E, Brennan T. How I wish to be remembered: the use of an advance care planning document in adolescent and young adult populations. J Palliat Med 2008;11:13091313.

    • Search Google Scholar
    • Export Citation
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