Hodgkin Lymphoma, Version 2.2012 Featured Updates to the NCCN Guidelines

Authors:
Richard T. Hoppe From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Ranjana H. Advani From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Weiyun Z. Ai From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Richard F. Ambinder From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Patricia Aoun From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Celeste M. Bello From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Philip J. Bierman From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Kristie A. Blum From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Robert Chen From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Bouthaina Dabaja From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Ysabel Duron From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Andres Forero From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Leo I. Gordon From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Francisco J. Hernandez-Ilizaliturri From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Ephraim P. Hochberg From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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David G. Maloney From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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David Mansur From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Peter M. Mauch From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Monika Metzger From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Joseph O. Moore From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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David Morgan From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Craig H. Moskowitz From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Matthew Poppe From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Barbara Pro From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Jane N. Winter From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Joachim Yahalom From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Hema Sundar From Stanford Cancer Institute; UCSF Hellen Diller Family Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UNMC Eppley Cancer Center at The Nebraska Medical Center; H. Lee Moffitt Cancer Center & Research Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; City of Hope Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Latinas Contra Cancer; University of Alabama at Birmingham Comprehensive Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Cancer Institute; Massachusetts General Hospital Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Dana-Farber/Brigham and Women’s Cancer Center; St. Jude Children’s Research Hospital/University of Tennessee Cancer Institute; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Memorial Sloan-Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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Volume/Issue:
Volume 10: Issue 5
Online Publication Date:
May 2012
DOI:
https://doi.org/10.6004/jnccn.2012.0061
Restricted access

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Hodgkin Lymphoma (HL) include the clinical management of classical HL and lymphocyte-predominant HL (LPHL). Major changes have been incorporated into these guidelines since their inception. In the 2012 NCCN Guidelines for HL, PET scans are not recommended for interim restaging of patients with stage I to II favorable disease. After reevaluating the available evidence on the use of interim PET imaging, the panel recommends the use of diagnostic CT scan of involved sites for interim restaging after completion of chemotherapy for this group of patients. Maintenance rituximab for 2 years is included as an option for patients with stage IB to IIB or stage III to IV LPHL treated with rituximab alone in the first-line setting. Brentuximab vedotin is included as an option for patients with progressive disease or relapsed disease after second-line chemotherapy or high-dose therapy with autologous stem cell rescue.

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  • 1

    Cheson BD. Role of functional imaging in the management of lymphoma. J Clin Oncol 2011;29:1844–1854.

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    Kuruvilla J, Keating A, Crump M. How I treat relapsed and refractory Hodgkin lymphoma. Blood 2011;117:4208–4217.

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    Younes A, Bartlett NL, Leonard JP et al.. Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N Engl J Med 2010;363:1812–1821.

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    Maeda LS, Advani RH. The emerging role for rituximab in the treatment of nodular lymphocyte predominant Hodgkin lymphoma. Curr Opin Oncol 2009;21:397–400.

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    Hutchings M, Mikhaeel NG, Fields PA et al.. Prognostic value of interim FDG-PET after two or three cycles of chemotherapy in Hodgkin lymphoma. Ann Oncol 2005;16:1160–1168.

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  • 6

    Sher DJ, Mauch PM, Van Den Abbeele A et al.. Prognostic significance of mid- and post-ABVD PET imaging in Hodgkin’s lymphoma: the importance of involved-field radiotherapy. Ann Oncol 2009;20:1848–1853.

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  • 7

    Barnes JA, LaCasce AS, Zukotynski K et al.. End-of-treatment but not interim PET scan predicts outcome in nonbulky limited-stage Hodgkin’s lymphoma. Ann Oncol 2011;22:910–915.

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  • 8

    Straus DJ, Johnson JL, LaCasce AS et al.. Doxorubicin, vinblastine, and gemcitabine (CALGB 50203) for stage I/II nonbulky Hodgkin lymphoma: pretreatment prognostic factors and interim PET. Blood 2011;117:5314–5320.

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  • 9

    Terasawa T, Lau J, Bardet S et al.. Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkin’s lymphoma and diffuse large B-cell lymphoma: a systematic review. J Clin Oncol 2009;27:1906–1914.

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Copyright:
Copyright © 2012 by the National Comprehensive Cancer Network 2012
Page Numbers:
9
Article Category:
Research Article
Print Publication Date:
01 May 2012
Online Publication Date:
May 2012
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