Research Priorities in Geriatric Oncology: Addressing the Needs of an Aging Population

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Dr. Arti Hurria is a geriatrician and oncologist. She completed a geriatric fellowship at Harvard, followed by a hematology-oncology fellowship at Memorial Sloan-Kettering Cancer Center. In 2006, Dr. Hurria joined the City of Hope as Director of the Cancer and Aging Research Program. She is vice chair of the Alliance Cancer in the Elderly Committee and a recipient of the Paul Beeson Career Development Award in Aging Research (K23 AG026749-01), among other awards. She is Editor-in-Chief of the Journal of Geriatric Oncology and chair of the NCCN Senior Adult Oncology Panel and has served as PI on multiple studies to improve clinical care for older adults with cancer.

Supriya Gupta Mohile, MD, is an Associate Professor of Medicine in Hematology/Oncology at the James Wilmot Cancer Center. She is a board-certified geriatrician and oncologist with clinical expertise in treating patients with genitourinary and gastrointestinal cancers. A graduate of Pennsylvania State University, she earned her MD at Thomas Jefferson Medical School. She completed internship, residency, and fellowships in hematology/oncology and geriatrics at University of Chicago Medical Center, where she also earned a master’s degree in health outcomes research. She has received an American Society of Clinical Oncology Young Investigator Award and Merit Awards, among others.

William Dale, MD, PhD, is an Associate Professor of Medicine and the Section Chief of Geriatrics and Palliative Medicine at the University of Chicago with a secondary appointment in Hematology/Oncology. He is a board-certified geriatrician with a doctorate in health policy. In 2006, Dr. Dale established, and he now codirects, the Specialized Oncology Care & Research in the Elderly (SOCARE) Clinic at the University of Chicago, which offers interdisciplinary, individualized, and integrated treatment to older cancer patients.

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    Smith BD, Smith GL, Hurria A. Future of cancer incidence in the United States: burdens upon an aging, changing nation. J Clin Oncol 2009;27:27582765.

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    Lewis JH, Kilgore ML, Goldman DP. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol 2003;21:13831389.

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    Murthy VH, Krumholz HM, Gross CP. Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA 2004;291:27202726.

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    Talarico L, Chen G, Pazdur R. Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration. J Clin Oncol 2004;22:46264631.

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    Sehl M, Sawhney R, Naeim A. Physiologic aspects of aging: impact on cancer management and decision making, part II. Cancer J 2005;11:461473.

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  • 6

    Hurria A, Togawa K, Mohile SG. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol 2011;29:34573465.

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  • 7

    Hurria A, Cohen HJ, Extermann M. Geriatric oncology research in the cooperative groups: a report of a SIOG Special Meeting. J Geriatr Oncol 2010;1:4044.

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  • 8

    Extermann M, Boler I, Reich RR. Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score. Cancer 2011; in press.

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  • 9

    Hurria A, Cirrincione CT, Muss HB. Implementing a geriatric assessment in cooperative group clinical cancer trials: CALGB 360401. J Clin Oncol 2011;29:12901296.

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  • 10

    Hurria A, Li D, Hansen K. Distress in older patients with cancer. J Clin Oncol 2009;27:43464351.

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    Diab SG, Elledge RM, Clark GM. Tumor characteristics and clinical outcome of elderly women with breast cancer. J Natl Cancer Inst 2000;92:550556.

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  • 12

    Klepin HD, Balducci L. Acute myelogenous leukemia in older adults. Oncologist 2009;14:222232.

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